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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
23.64
Human Site:
T395
Identified Species:
37.14
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
T395
H
P
D
F
D
A
S
T
L
Y
V
P
E
D
F
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
T395
H
P
D
F
N
A
S
T
L
Y
V
P
E
D
F
Dog
Lupus familis
XP_531814
1283
145094
L369
A
L
T
G
V
N
E
L
G
L
V
F
M
K
G
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
T394
H
P
E
F
N
P
T
T
L
Y
V
P
E
E
F
Rat
Rattus norvegicus
XP_002726765
1361
151628
T397
H
P
D
Y
N
S
S
T
L
Y
V
P
E
D
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
P501
Q
N
H
P
D
Y
D
P
C
T
L
Y
V
P
E
Frog
Xenopus laevis
NP_001089247
1340
149481
T374
D
A
D
Y
D
P
S
T
L
Y
I
P
D
D
F
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
T394
D
E
N
Y
D
P
T
T
L
Y
V
P
E
D
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
L290
K
V
G
K
F
Y
E
L
Y
H
M
D
A
D
V
Honey Bee
Apis mellifera
XP_392346
1120
127429
Q220
V
P
L
D
F
L
N
Q
Q
T
P
A
M
R
Q
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
E286
T
Y
H
M
D
A
V
E
V
V
R
A
L
N
I
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
G367
P
T
S
R
K
T
F
G
T
P
S
V
S
S
T
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
V376
E
K
N
F
S
L
N
V
E
K
L
A
R
K
G
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
T368
D
E
N
Y
D
P
R
T
L
Y
L
P
P
D
F
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
E342
G
K
F
F
E
L
Y
E
K
D
A
L
L
A
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
93.3
6.6
N.A.
66.6
80
N.A.
N.A.
6.6
60
60
N.A.
6.6
6.6
13.3
0
P-Site Similarity:
100
N.A.
100
6.6
N.A.
93.3
100
N.A.
N.A.
13.3
80
80
N.A.
20
13.3
26.6
0
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
6.6
N.A.
N.A.
46.6
6.6
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
66.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
0
0
0
20
0
0
0
0
7
20
7
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% C
% Asp:
20
0
27
7
40
0
7
0
0
7
0
7
7
47
0
% D
% Glu:
7
14
7
0
7
0
14
14
7
0
0
0
34
7
7
% E
% Phe:
0
0
7
34
14
0
7
0
0
0
0
7
0
0
47
% F
% Gly:
7
0
7
7
0
0
0
7
7
0
0
0
0
0
14
% G
% His:
27
0
14
0
0
0
0
0
0
7
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
7
% I
% Lys:
7
14
0
7
7
0
0
0
7
7
0
0
0
14
0
% K
% Leu:
0
7
7
0
0
20
0
14
47
7
20
7
14
0
0
% L
% Met:
0
0
0
7
0
0
0
0
0
0
7
0
14
0
0
% M
% Asn:
0
7
20
0
20
7
14
0
0
0
0
0
0
7
7
% N
% Pro:
7
34
0
7
0
27
0
7
0
7
7
47
7
7
0
% P
% Gln:
7
0
0
0
0
0
0
7
7
0
0
0
0
0
7
% Q
% Arg:
0
0
0
7
0
0
7
0
0
0
7
0
7
7
0
% R
% Ser:
0
0
7
0
7
7
27
0
0
0
7
0
7
7
0
% S
% Thr:
7
7
7
0
0
7
14
47
7
14
0
0
0
0
7
% T
% Val:
7
7
0
0
7
0
7
7
7
7
40
7
7
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
27
0
14
7
0
7
47
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _